Application of automated liquid handling in ligand-binding assay-based bioanalytical method development: the practical considerations

Practical Considerations of Liquid Handling Devices in Drug Discovery

The application and development of graph theory through the space syntax method: The implementation of analytical practical model in architecture

Abstract Over the last few decades, different mathematical methods have been used to design and analyze architectural spaces. Meanwhile, the graph theory provides an abstract model to study the spatial configuration, so that a simple and flexible mathematical framework is obtained to analyze the spatial topological features and their relationship with social and functional concepts in architec...

Automate it: ligand-binding assay productivity in a discovery bioanalytical setting.

In multiple industries, including the biopharmaceutical industry, automation is synonymous with increased productivity. Environments with high-throughput needs commonly employ automation for efficiency. However, in a discovery bioanalytical ligand-binding assay laboratory setting where the focus is not necessarily on sample analysis throughput, but instead on assay development and characterizat...

Development of a new method based on chiral ligand-exchange chromatography for the enantioseparation of propranolol

A new chromatographic procedure was proposed for the separation of propranolol (PRN) enantiomers based upon enantioselective chiral ligand-exchange chromatography. The separation was carried out on a short C8 column leading to considerably short separation time. L-alanine and Cu2+ were applied as chiral selector and central bivalent complexing ion, respectively. It was found that the kind of co...

Development of a new method based on chiral ligand-exchange chromatography for the enantioseparation of propranolol

A new chromatographic procedure was proposed for the separation of propranolol (PRN) enantiomers based upon enantioselective chiral ligand-exchange chromatography. The separation was carried out on a short C8 column leading to considerably short separation time. L-alanine and Cu2+ were applied as chiral selector and central bivalent complexing ion, respectively. It was found that the kind of co...